

Alphamissense
Overview :
AlphaMissense is an open-source protein variant effect prediction model that predicts theFunctional impact of all possible human amino acid substitutions. It employs deep learning to predict at the protein sequence level without requiring experimental structural information. AlphaMissense can accurately predict the functional impacts of pathogenic variants that have been verified by cell experiments, which is significant for drug design and the study of genetic diseases.
Target Users :
["Drug Design","Study of Genetic Diseases","Protein Engineering"]
Use Cases
Predicting the pathogenicity of unknown variants in the BRCA1 gene using AlphaMissense
Predicting the effect of amino acid substitutions on ligand affinity in GPCR receptor proteins using AlphaMissense
Designing BRCA1 protein variants for structural biology research based on the results of AlphaMissense
Features
Predicts the functional impact of amino acid substitutions using deep learning
No protein structural information needed; predictions are based solely on sequences
Provides predictions for all possible human amino acid substitutions
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